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Health and Diseases » Diabetes » Anti diabetic drug Glyburide reduce mortality risk in diabetes patients with melioidosis

Anti diabetic drug Glyburide reduce mortality risk in diabetes patients with melioidosis

In meliodosis patients, there is a risk for mortality, and diabetes is one of risk factor leading to this disease.
Melioidosis itself caused by gram-negative bacteria burkholderia pseudomallei that manifests in the acute form of chronic infection mimics tuberculosis with fever, abscesses, and pneumonia.

It is estimated about half of melioidosis patients had diabetes.

In a study among 1160 patients with gram-negative sepsis caused by burkholderia in northeast Thailand from 2002 to 2006, which has the highest prevalence of the disease worldwide, the researchers found that diabetic drug Glyburide reduced mortality risk in diabetic patients with melioidosis.

According to study authors, Dr. Gavin C.K.W. Koh, from Addenbrooke’s Hospital, Cambridge, UK, and colleagues, the melioidosis-related mortality was 28% in diabetics on glyburide, 48% among patients on other antidiabetics, 47% in those with newly diagnosed hyperglycemia, and 45% among non-diabetics.

Reported in Clinical Infectious Diseases on February 3, 2011, from logistic regression analysis, survival was significantly greater in the glyburide group, with an adjusted odds ratio of 0.47.

Also, they added that the leukocyte gene expressionwas significantly different in patients taking glyburide, with down-regulation of genes associated with production of inflammatory mediators by neutrophils.

According the team, the anti-inflammatory effects of glyburide are probably mediated through its inhibition of the “inflammasomes”, a group of intracellular proteins involved in the activation of interleukins.

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