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Health and Diseases » Atrial Fibrillation » Rivaroxaban not superior to warfarin in preventing stroke and major embolism in AF patients

Rivaroxaban not superior to warfarin in preventing stroke and major embolism in AF patients

While previous scientific session at the American Heart Association (AHA) in 2010 showed that Rivaroxaban (Xarelto, Bayer/Johnson & Johnson) was not superior to Warfarin in preventing stroke and non-central nervous system (CNS) embolism in patients with atrial fibrillation (AF), currently the researchers concluded that this oral anticoagulant really not superior to warfarin on major embolism and stroke prevention for AF patients.

However, this drug showed better in patients treated only with the drug in an on-treatment comparison which is significantly showed reduced the risk of stroke and non-CNS embolization 21% compared with warfarin.

This conclusion based on ROCKET-AF trial led by Dr. Manesh Patel from Duke Clinical Research Institute, Durham, NC.

The trial involved 14,264 patients with nonvalvular atrial fibrillation who were at an increased risk of stroke, such as those with prior history of stroke and those with a history of hypertension. In addition, 90% of patients had a CHADS2 score of 3 or higher, higher than scores of AF patients enrolled in other antithrombotic trials.

Since the trial showed no superior of rivaroxaban to dose-adjusted warfarin, in accompanying editorial, Dr. Gregory del Zoppo from the University of Washington School of Medicine, Seattle, and Dr. Misha Eliaszie from the University of Calgary, AB, write that instead of clarifying the noninferiority/superiority question, the editorialists believe that “the multiple analyses have muddied the waters regarding rivaroxaban’s efficacy and effectiveness over warfarin.”

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One Response to "Rivaroxaban not superior to warfarin in preventing stroke and major embolism in AF patients"

  1. Teena Baral says:

    Seriously I would recommend getting the time and know how. Throwing money at an investment is a sure way to lose it all.

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