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Health and Diseases » Schizophrenia and Bipolar Disorder » High dose antipsychotics Quetiapine no help in improving schizophrenia symptoms

High dose antipsychotics Quetiapine no help in improving schizophrenia symptoms

Quetiapine is an antipsychotic drug for patients with schizophrenia or bipolar disorder.
However, these drugs often used in high dose without adequate supporting data from the benefits of such action.

While the use of quetiapine should be discontinued gradually and provide some potential side effects, the benefits of high doses also not useful in improving schizophrenia symptoms. In fact, the patient’s weight tend to rise.

This conclusion is obtained after the researchers conducted a randomized trial for patients receiving approved-dose (800 mg/day) as a placebo group (43 patients) and a group with higher dose of 1,144 mg/day (88 patients).

The improvement of schizophrenia symptoms measured with Positive and Negative Syndrome Scale (PANSS) score after treatment.

Reported in the Journal of Clinical Psychiatry on June 14, 2011, the study authors, Dr. William G. Honer from the British Columbia Mental Health and Addiction Research Institute in Vancouver and colleagues said that high dose group showed more frequent of emerging or worsening parkinsonism (3.1%) than placebo group, weight increased about 1.7 kg (12.5% gained from baseline weight) in 7% of subjects at the high dose group compared with 1.1 kg increased to 9.3% of subjects in the placebo group

Overall, despite the severity in both groups showed declined over time without any striking differences, high dose of quetiapine did not provide more benefit than approved-dose as current recommendation.

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