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PPIs discontinuation after erosive esopaghitis therapy won’t cause heartburn again or even worse

Previous studies said that increased excessive acid secretion through indicator of Gastrin levels which may cause Heartburn can re-occur if the use of proton pump inhibitors (PPIs) discontinued in the patients who already have erosive esopaghitis therapy, including can cause acid-related symptoms if stopped for a while. However, from recent study conducted by researchers from the University of Pennsylvania said that the effects doesn’t like that. According to current study authors, increased gastrin levels after PPIs discontinuation will return to normal within a month and remain flat thereafter. The results of this study were reported in the American Journal of Gastroenterology on August 16, 2011, and based on reviewed data from 4 phase III trials involved 287 patients with a negative indication for Helicobacter pylori. While there is no long run of increased gastrin … Read entire article »

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